abstract：:Alzheimer's disease (AD), the most common form of dementia, is characterized by the loss of normal functions of brain cells and neuronal death, ultimately leading to memory loss. Recent accumulating evidences have demonstrated the therapeutic potential of anti-diabetic agents, such as dipeptidyl peptidase-4 (DPP-4) in...

journal_title：Behavioural brain research

authors： Kosaraju J,Madhunapantula SV,Chinni S,Khatwal RB,Dubala A,Muthureddy Nataraj SK,Basavan D

更新日期：2014-07-01 00:00:00

abstract：:It has been reported that training in behavioral tasks modifies the ability to induce long-term potentiation (LTP) in an N-methyl-D-aspartate receptor (NMDAR)-dependent manner. This receptor leads to calcium entry into neuronal cells, promoting the activation of protein kinases as protein kinase A (PKA) and protein ki...

journal_title：Behavioural brain research

authors： Rodríguez-Durán LF,Escobar ML

更新日期：2014-06-01 00:00:00

abstract：:Deep brain stimulation (DBS) has been shown to be effective for relief of Parkinson's disease, depression and obsessive-compulsive disorder in humans, but the effect of DBS on psychosis is largely unknown. In previous studies, we showed that inactivation of the medial septum or nucleus accumbens normalized the hyperac...

journal_title：Behavioural brain research

authors： Ma J,Leung LS

更新日期：2014-06-01 00:00:00

abstract：:Depression and substance-abuse (e.g., cocaine) disorders are common concurrent diagnoses. In the present study, we combined bilateral olfactory bulbectomy (OBX) with a variety of procedures of intravenous cocaine self-administration and extinction/reinstatement in rats. We also investigated the effects of N-acetylcyst...

journal_title：Behavioural brain research

authors： Frankowska M,Jastrzębska J,Nowak E,Białko M,Przegaliński E,Filip M

更新日期：2014-06-01 00:00:00

abstract：:The central 5-hydroxytryptamine (5-HT; serotonin) system is well established as an important regulator of appetite and continues to remain a focus of obesity research. While much emphasis has focussed on the 5-HT(2C) receptor (5-HT(2C)R) in 5-HT's anorectic effect, pharmacological manipulation of the 5-HT₆ receptor (5...

journal_title：Behavioural brain research

authors： Garfield AS,Burke LK,Shaw J,Evans ML,Heisler LK

更新日期：2014-06-01 00:00:00

abstract：:An enriched environment has been shown to influence brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF). BDNF, which is synthesized as a precursor molecule (proBDNF) that undergoes proteolytic cleavage, plays an important role in synaptic plasticity and contributes to seve...

journal_title：Behavioural brain research

authors： Cao W,Duan J,Wang X,Zhong X,Hu Z,Huang F,Wang H,Zhang J,Li F,Zhang J,Luo X,Li CQ

更新日期：2014-05-15 00:00:00

abstract：:It is yet unclear if ethanol-induced motor stimulation in the open field (OF) merely reflects psychomotor stimulating effects of the drug or if this stimulation is driven or modulated by ethanol's antianxiety properties. In the present study, adolescent rats were administered with different ethanol doses or remained u...

journal_title：Behavioural brain research

authors： Acevedo MB,Nizhnikov ME,Molina JC,Pautassi RM

更新日期：2014-05-15 00:00:00

abstract：:The present study investigated the effects of a single intravenous (i.v.) dose of Vitamin C (ascorbate, ASC) on spatial memory in APP/PSEN1 mice, an Alzheimer's disease model. First, we confirmed the uptake time course in ASC-depleted gulo (-/-) mice, which cannot synthesize ASC. Differential tissue uptake was seen ba...

journal_title：Behavioural brain research

authors： Kennard JA,Harrison FE

更新日期：2014-05-01 00:00:00

abstract：:Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel ...

journal_title：Behavioural brain research

authors： Eagle DM,Noschang C,d'Angelo LS,Noble CA,Day JO,Dongelmans ML,Theobald DE,Mar AC,Urcelay GP,Morein-Zamir S,Robbins TW

更新日期：2014-05-01 00:00:00

abstract：:Protein phosphorylation is a well-known and well-documented mechanism in memory processes. Although a large series of protein kinases involved in memory processes have been reported, information on phosphoproteins is limited. It was therefore the aim of the study to determine a partial and differential phosphoproteome...

journal_title：Behavioural brain research

authors： Li L,Csaszar E,Szodorai E,Patil S,Pollak A,Lubec G

更新日期：2014-05-01 00:00:00

abstract：:In both a behavioural and neuroimaging study, we examined whether memory performance and the pattern of brain activation during a word recognition task differed depending on the type of visual context presented during encoding. Participants were presented with a list of words, paired with either a picture of famous fa...

journal_title：Behavioural brain research

authors： Skinner EI,Manios M,Fugelsang J,Fernandes MA

更新日期：2014-05-01 00:00:00

abstract：:Serotonergic neurons in the dorsal raphe nucleus (DR) are organized in anatomically distinct subregions that form connections with specific brain structures to modulate diverse behaviors, including anxiety-like behavior. It is unclear if the functional heterogeneity of these neurons is coupled to their developmental h...

journal_title：Behavioural brain research

authors： Brooks LR,Enix CL,Rich SC,Magno JA,Lowry CA,Tsai PS

更新日期：2014-05-01 00:00:00

abstract：:In order to investigate the role of brain-derived neurotrophic factor (BDNF) in the consolidation of spatial memory, we examined the relationship between the increase of hippocampal BDNF and the establishment of long-term spatial memory in spontaneous place recognition test in rats. The test consisted of a sample phas...

journal_title：Behavioural brain research

authors： Ozawa T,Yamada K,Ichitani Y

更新日期：2014-04-15 00:00:00

abstract：:Smoking is linked to post-traumatic stress disorder (PTSD) which suggests smoking is either a risk factor or an attempt at self-medication. The ability to reduce or extinguish fear-related memories may be altered in patients with PTSD and it is possible that nicotine modulates this. Although there are numerous studies...

journal_title：Behavioural brain research

authors： Kutlu MG,Gould TJ

更新日期：2014-04-15 00:00:00

abstract：:Working memory (WM) refers to the short-term maintenance of information with higher cognitive functions. Recent researches show that local field potentials (LFPs) and spikes, as different modes of neural signals, encode WM, respectively. There is a growing interest in how these two signals encode WM in coordination. T...

journal_title：Behavioural brain research

authors： Li S,Ouyang M,Liu T,Bai W,Yi H,Tian X

更新日期：2014-03-15 00:00:00

abstract：:Previous studies in our laboratory have demonstrated that piperine produced antidepressant-like action in various mouse models of behavioral despair. This study aimed to investigate the role of brain-derived neurotrophic factor (BDNF) signalling in the antidepressant-like effect of piperine in mice exposed to chronic ...

journal_title：Behavioural brain research

authors： Mao QQ,Huang Z,Zhong XM,Xian YF,Ip SP

更新日期：2014-03-15 00:00:00

abstract：:The median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Other studies have indica...

journal_title：Behavioural brain research

authors： Shim I,Stratford TR,Wirtshafter D

更新日期：2014-03-15 00:00:00

abstract：:Postnatal maternal separation (PMS) has been shown to be associated with an increased vulnerability to psychiatric illnesses in adulthood. However, the underlying neurological mechanisms are not well understood. Here we evaluated its effects on neurogenesis and tonic GABA currents of cortical layer 5 (L5) pyramidal ne...

journal_title：Behavioural brain research

authors： Feng M,Sheng G,Li Z,Wang J,Ren K,Jin X,Jiang K

更新日期：2014-03-01 00:00:00

abstract：:Nedd4 is a widely expressed ubiquitin ligase that is necessary for normal neuronal development and function. However, largely due to the lethality of Nedd4 homozygous knockout mice, little is known about the physiological roles of Nedd4 in the adult brain. In this study we used Nedd4 heterozygous mice, which are viabl...

journal_title：Behavioural brain research

authors： Camera D,Boase NA,Kumar S,Pow DV,Poronnik P

更新日期：2014-03-01 00:00:00

abstract：:Previous work examining animal models of cognitive flexibility have focused on tasks where animals are required to shift between cues in order to reach a food reward from among a limited set of choices. Performance by nonhuman animals on these tasks, including reversal learning, intradimensional set-shifting, and extr...

journal_title：Behavioural brain research

authors： Hecht PM,Will MJ,Schachtman TR,Welby LM,Beversdorf DQ

更新日期：2014-03-01 00:00:00

abstract：:These experiments were designed to determine if prior sexual experience reduced the negative effect of mild stress on female sexual behavior. In the first experiment, ovariectomized rats were hormonally primed with estradiol benzoate and progesterone for 3 consecutive weeks during which they received six mating experi...

journal_title：Behavioural brain research

authors： Uphouse L,Hiegel C,Adams S,Murillo V,Martinez M

更新日期：2014-02-01 00:00:00

abstract：:The present study aimed at determining whether or not the comprehension of symbolic gestures, and corresponding-in-meaning words, makes use of cortical circuits involved in movement execution control. Participants were presented with videos of an actress producing meaningful or meaningless gestures, pronouncing corres...

journal_title：Behavioural brain research

authors： Campione GC,De Stefani E,Innocenti A,De Marco D,Gough PM,Buccino G,Gentilucci M

更新日期：2014-02-01 00:00:00

abstract：:Both the serotonin and glutamate systems have been implicated in the pathophysiology of schizophrenia, as well as in the mechanism of action of antipsychotic drugs. Psychedelic drugs act through the serotonin 2A receptor (5-HT2AR), and elicit a head-twitch response (HTR) in mice, which directly correlates to 5-HT2AR a...

journal_title：Behavioural brain research

authors： Santini MA,Balu DT,Puhl MD,Hill-Smith TE,Berg AR,Lucki I,Mikkelsen JD,Coyle JT

更新日期：2014-02-01 00:00:00

abstract：:The outcome of behavioral interactions between organisms can have significant fitness implications. Therefore, it is of great theoretical and practical importance to understand the mechanisms that modify different agonistic behaviors. Changes in central monoamines, such as serotonin (5-HT), contribute to modifying the...

journal_title：Behavioural brain research

authors： Bubak AN,Renner KJ,Swallow JG

更新日期：2014-02-01 00:00:00

abstract：:Neuromedin U (NmU) is a widely distributed and multifunctional peptide in the central nervous system and the peripheral tissues. Little is know about the mechanisms of NmU on brain functions. The rodent isoform of the NmU, NmU-23, has been shown to have anxiolytic effects involved in the β-adrenergic and cholinergic n...

journal_title：Behavioural brain research

authors： Tanaka M,Telegdy G

更新日期：2014-02-01 00:00:00

abstract：:Epilepsy is a relatively common and chronic neurological condition, affecting 1-2% of the population. However, understanding of the underlying pathophysiology remains incomplete. To identify potential factors in the early environment that may increase the risk for experiencing seizures, maternal stress and environment...

journal_title：Behavioural brain research

authors： Korgan AC,Green AD,Perrot TS,Esser MJ

更新日期：2014-02-01 00:00:00

abstract：:Although fear extinction requires N-methyl-d-aspartate (NMDA) receptor signaling, Cav2.1-regulated synaptic function in extinction remains unknown. This study examined whether Cav2.1-mediated signaling plays role in consolidation of extinction. Wild-type mice received intracerebroventricular injection of Cav2.1 blocke...

journal_title：Behavioural brain research

authors： Niimi K,Han Y,Zhou Y,Yoshimoto T,Dai F,Teng X,Tian X,Li W,Takahashi E

更新日期：2014-02-01 00:00:00

abstract：:Bizarre behaviors (stereotyped stretching, stereotyped rearing, backward movements and jumps) were conspicuously elicited in classical unconditioned tests with different levels of anxiogenic conditions. They were characterized for the first time as early-BPSD-like symptoms in 6 month-old male and female 3xTg-AD mice. ...

journal_title：Behavioural brain research

authors： Baeta-Corral R,Giménez-Llort L

更新日期：2014-01-01 00:00:00

abstract：:Humans can perform, perceive, and imagine voluntary movement. Numerous investigations of these abilities have employed variants of goal-directed aiming tasks because the Fitts's law equation reliably captures the mathematical relationship between movement time (MT) and accuracy requirements. The emergence of Fitts's s...

journal_title：Behavioural brain research

authors： Wong L,Manson GA,Tremblay L,Welsh TN

更新日期：2013-11-15 00:00:00

abstract：:Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption u...

journal_title：Behavioural brain research

authors： Blouin AM,Lee JJ,Tao B,Smith DR,Johnson AW,Baraban JM,Reti IM

更新日期：2013-11-15 00:00:00

abstract：:The present study assessed the spatial abilities of male and female human participants using different versions of the non-navigational Corsi block-tapping test (CBT) and a search task. Males performed significantly better than females on the standard manual version of the CBT; however, the standard CBT does not allow...

journal_title：Behavioural brain research

authors： Shah DS,Prados J,Gamble J,De Lillo C,Gibson CL

更新日期：2013-11-15 00:00:00

abstract：:Many forms of human psychopathology are characterized by sustained negative emotional responses to threat and chronic behavioral avoidance, implicating avoidance as a potential transdiagnostic factor. Evidence from both nonhuman neurophysiological and human neuroimaging studies suggests a distributed frontal-limbic-st...

journal_title：Behavioural brain research

authors： Schlund MW,Hudgins CD,Magee S,Dymond S

更新日期：2013-11-15 00:00:00

abstract：:Hormonally induced mood disorders such as premenstrual dysphoric disorder (PMDD) are characterized by a range of physical and affective symptoms including anxiety, irritability, anhedonia, social withdrawal and depression. Studies demonstrated rodent models of progesterone withdrawal (PWD) have a high level of constru...

journal_title：Behavioural brain research

authors： Li Y,Raaby KF,Sánchez C,Gulinello M

更新日期：2013-11-01 00:00:00

abstract：:Icariin is a major constituent of flavonoids isolated from Herba Epimedii. Several previous studies have demonstrated the antidepressant-like effects of icariin. After oral administration of icariin, 19 metabolites of icariin were detected in rat plasma. Icaritin is one such of metabolite of icariin. In this study, a ...

journal_title：Behavioural brain research

authors： Wu X,Wu J,Xia S,Li B,Dong J

更新日期：2013-11-01 00:00:00

abstract：:The exposure to stress has been associated with increased depressive and anxiety symptoms, yet not all individuals respond negatively to the experience of stress. Recent rodent social defeat models demonstrate similar individual differences in response to social stress. In particular, mice subjected to chronic social ...

journal_title：Behavioural brain research

authors： Meduri JD,Farnbauch LA,Jasnow AM

更新日期：2013-11-01 00:00:00

abstract：:Genes and proteins of the Fos family are used as markers of neuronal activity and can be modulated by stress. This study investigated whether social defeat (SD) or exposure to an olfactory cue associated with the SD experience activated Fos and FosB/DeltaFosB (ΔFosB) expression in brain regions implicated in the devel...

journal_title：Behavioural brain research

authors： Bourne AR,Mohan G,Stone MF,Pham MQ,Schultz CR,Meyerhoff JL,Lumley LA

更新日期：2013-11-01 00:00:00

abstract：:Prenatal ethanol exposure can lead to long-lasting impairments in the ability of rats to process spatial information, as well as produce long-lasting deficits in long-term potentiation (LTP), a biological model of learning and memory processing. The present study aimed to examine the sexually dimorphic effects of chro...

journal_title：Behavioural brain research

authors： An L,Zhang T

更新日期：2013-11-01 00:00:00

abstract：:Alzheimer's disease (AD), can be described as a vascular disorder, is characterized by endothelial and platelet activation. One feature of activated cells is loss of lipid asymmetry, and membrane blebbing which cause microparticle (MP) formation. MPs increased under many pathological states and little information is a...

journal_title：Behavioural brain research

authors： Hosseinzadeh S,Zahmatkesh M,Zarrindast MR,Hassanzadeh GR,Karimian M,Sarrafnejad A

更新日期：2013-11-01 00:00:00

abstract：:Studies indicate that histone deacetylation is important for long term changes related to stress and antidepressant treatment. The present study aimed to evaluate the effects of the classic antidepressant imipramine, and of an antagonist of the N-methyl-d-asparte (NMDA) receptor, ketamine, on behavior and histone deac...

journal_title：Behavioural brain research

authors： Réus GZ,Abelaira HM,dos Santos MA,Carlessi AS,Tomaz DB,Neotti MV,Liranço JL,Gubert C,Barth M,Kapczinski F,Quevedo J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:According to the incentive sensitization theory, addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems. After repeated ethanol administration, some animals develop psychomotor sensitization, a phenomenon which occurs simultaneously with the incentive sensitization...

journal_title：Behavioural brain research

authors： Kim AK,Souza-Formigoni ML

更新日期：2013-11-01 00:00:00